As the San Francisco 49ers prepare for their highly anticipated game against the New England Patriots, the team has provided a crucial injury update that could significantly impact the outcome of this marquee matchup. Several key players are currently dealing with injuries, raising questions about their availability for Sunday’s game.

The 49ers’ standout tight end, George Kittle, remains on the injury report due to lingering knee soreness. Although he’s been a game-changer when healthy, his status for the upcoming contest is still uncertain. The coaching staff will likely make a game-time decision, leaving fans in suspense over whether the offensive powerhouse will take the field.

Meanwhile, star defensive end Nick Bosa, who has been battling a minor hamstring injury, is listed as questionable. The 49ers’ defensive unit has leaned heavily on Bosa’s ability to disrupt the opposing offense, and his absence could pose a significant challenge for the team as they look to contain the Patriots’ versatile offense. Bosa has been practicing in a limited capacity, but his full recovery remains in doubt.

Additionally, the offensive line has been hit with some concerns, as starting left tackle Trent Williams has been dealing with an ankle sprain. His potential absence would be a major blow, as Williams is a key protector for quarterback Brock Purdy and essential in the 49ers’ running game.